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Section
Hematology and Oncology
Hematology and Oncology
Anemias Caused by Deficient Erythropoiesis
Introduction
Anemia of Chronic Disease
Etiology
Diagnosis
Treatment
Aplastic Anemia
Etiology
Symptoms and Signs
Diagnosis
Treatment
Hypoproliferative Anemias
Anemia of renal disease
Other hypoproliferative anemias
Iron Deficiency Anemia
Pathophysiology
Iron absorption
Iron transport and usage
Iron storage and recycling
Iron deficiency
Etiology
Symptoms and Signs
Diagnosis
Treatment
Megaloblastic Macrocytic Anemias
Etiology
Pathophysiology
Symptoms and Signs
Diagnosis
Treatment
Myelodysplasia and Iron-Transport Deficiency Anemia
Myelophthisic Anemia
Etiology
Symptoms and Signs
Diagnosis
Treatment
Sideroblastic Anemias
Anemias Caused by Hemolysis
Introduction
Etiology
Pathophysiology
Symptoms and Signs
Diagnosis
Treatment
Autoimmune Hemolytic Anemia
Etiology and Pathophysiology
Symptoms and Signs
Diagnosis
Treatment
Embden-Meyerhof Pathway Defects
Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency
Pathophysiology
Diagnosis and Treatment
Hemoglobin C Disease
Hemoglobin E Disease
Hemoglobin S-C Disease
Hemoglobin S–β-Thalassemia Disease
Hereditary Spherocytosis and Hereditary Elliptocytosis
Pathophysiology
Symptoms and Signs
Diagnosis
Treatment
Paroxysmal Nocturnal Hemoglobinuria (PNH)
Diagnosis
Treatment
Sickle Cell Anemia
Pathophysiology
Symptoms and Signs
Diagnosis
Prognosis and Treatment
Stomatocytosis and Anemia Caused by Hypophosphatemia
Stomatocytosis
Anemia caused by hypophosphatemia
Thalassemias
Etiology and Pathophysiology
Symptoms and Signs
Diagnosis
Prognosis and Treatment
Traumatic Hemolytic Anemia
Approach to the Patient With Anemia
Introduction
Etiology of Anemia
Evaluation of Anemia
History
Physical Examination
Testing
Treatment of Anemia
Bleeding Due to Abnormal Blood Vessels
Introduction
Autoerythrocyte Sensitization
Dysproteinemias Causing Vascular Purpura
Hereditary Hemorrhagic Telangiectasia
Symptoms, Signs, and Diagnosis
Treatment
Purpura Simplex
Senile Purpura
Coagulation Disorders
Introduction
Coagulation Disorders Caused by Circulating Anticoagulants
Factor VIII Anticoagulants
Disseminated Intravascular Coagulation (DIC)
Etiology and Pathophysiology
Symptoms and Signs
Diagnosis
Treatment
Hemophilia
Symptoms and Signs
Diagnosis
Prevention and Treatment
Uncommon Hereditary Coagulation Disorders
Eosinophilic Disorders
Introduction
Eosinophilia
Diagnosis and Treatment
Idiopathic Hypereosinophilic Syndrome
Symptoms, Signs, and Diagnosis
Prognosis and Treatment
Hemostasis
Introduction
Vascular Factors
Platelet Factors
Plasma Factors
Regulatory Mechanisms
Inactivation of coagulation factors
Fibrinolysis
Regulation of fibrinolysis
Approach to the Patient With a Possible Bleeding Disorder
Evaluation
History
Physical examination
Testing
Treatment
Histiocytic Syndromes
Introduction
Langerhans' Cell Histiocytosis
Symptoms and Signs
Eosinophilic granuloma
Hand-Schüller-Christian disease
Letterer-Siwe disease
Diagnosis
Prognosis and Treatment
Iron Overload
Introduction
Hemosiderosis
Primary Hemochromatosis
Etiology and Pathophysiology
Symptoms and Signs
Diagnosis
Treatment
Ferroportin Disease
Juvenile Hemochromatosis
Transferrin and Ceruloplasmin Deficiency
Secondary Iron Overload
Overload of Unknown Origin
Leukemias
Introduction
Etiology and Pathophysiology
Classification
Acute Leukemia
Symptoms and Signs
Diagnosis
Prognosis and Treatment
Supportive care
Acute Lymphocytic Leukemia (ALL)
Prognosis
Treatment
Relapse
Acute Myelocytic Leukemia (AML)
Prognosis and Treatment
Chronic Leukemia
Chronic Lymphocytic Leukemia (CLL)
Pathophysiology
Symptoms and Signs
Diagnosis
Prognosis and Treatment
Chemotherapy
Corticosteroid therapy
Monoclonal antibody therapy
Radiation therapy
Chronic Myelocytic Leukemia (CML)
Pathophysiology
Symptoms and Signs
Diagnosis
Prognosis
Treatment
Myelodysplastic Syndrome
Etiology and Pathophysiology
Symptoms and Signs
Diagnosis
Prognosis and Treatment
Lymphomas
Introduction
Hodgkin Lymphoma
Etiology and Pathophysiology
Symptoms and Signs
Diagnosis
Staging
Prognosis and Treatment
Complications of treatment
Non-Hodgkin Lymphomas
Etiology and Pathophysiology
Classification
Symptoms and Signs
Diagnosis
Staging
Prognosis
Treatment
Localized disease (stages I and II)
Advanced disease (stages III and IV)
Aggressive lymphoma relapse
Burkitt's Lymphoma
Mycosis Fungoides
Prognosis and Treatment
Myeloproliferative Disorders
Introduction
Essential Thrombocythemia
Etiology and Pathophysiology
Symptoms, Signs, and Diagnosis
Prognosis and Treatment
Thrombocytosis
Myelofibrosis
Etiology and Pathophysiology
Symptoms, Signs, and Diagnosis
Prognosis and Treatment
Polycythemia Vera
Pathophysiology
Symptoms and Signs
Diagnosis
Prognosis
Treatment
Phlebotomy
Myelosuppressive therapy
Treatment of complications
Secondary Erythrocytosis
Neutropenia and Lymphocytopenia
Introduction
Lymphocytopenia
Etiology
Symptoms and Signs
Diagnosis
Treatment
Neutropenia
Etiology
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